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The maximum life span of multicellular organisms varies greatly: for a fruitfly it is about 30 days, for a dog about 20 years, and for a human about 100 years. Despite these differences, all animals show a similar pattern of their life spans - growth, adulthood, and aging, followed by death. The basic cause of aging in multicellular organisms (eukaryotes) lies at the level of the genes, although nutrition and various types of stresses do influence the rate and pattern of aging. This book reviews the molecular biology of the gene in relation to aging. Until about a decade ago it was not possible to probe into the types of changes that occur in eukaryotic genes, due to their enormous complexity. The use of genetic engineering techniques, however, is beginning to unravel the changes that occur in the genes as an organism ages: such as the changing expression of specific genes under normal conditions and under various types of stress, the changes in the regulatory roles of the sequences in the promotor regions of genes, conformational changes that may occur in genes during aging, and the protein factors that are involved in the aging process. The author presents basic information on eukaryotic genes and follows this with details of the changes that occur in their structure and function during aging. He reviews the latest studies being carried out in various laboratories, outlines the gaps and deficiencies in our present knowledge and suggests the most profitable future areas of research. Genes and Aging is for all students and researchers interested in the molecular biology of aging.

Aging --- Cells --- Genetic aspects. --- Aging.

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Herpesvirus infections --- Herpesvirus infections --- Viral genetics. --- Genetic aspects. --- Pathogenesis.

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Cancer --- Genetic aspects --- NEOPLASMS --- NEOPLASTIC SYNDROMES, HEREDITARY --- ENVIRONMENTAL EXPOSURE --- GENETICS --- ETIOLOGY --- ADVERSE EFFECTS

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This work uniquely collates and summarizes our current knowledge of the structure and function of the genes and proteins involved in blood coagulation and/or its regulation. For the first time, the vast, rapidly growing and scattered literature has been comprehensively analyzed. The book presents critical reviews covering the entire field of the hereditary disorders of haemostasis and thrombosis. An introductory chapter outlines the most recent theories of blood coagulation and the state-of-the-art of the analysis of human gene mutation, followed by 32 chapters, each devoted to a single gene or small group of genes and their corresponding disorders. As well as detailing each gene's structure, chromosomal location and regulation, the authors provide concise but comprehensive summaries of each protein product and of the deficiency disorders associated therewith, whether leading to hemophilia or thrombophilia. Appendices contain essential practical information on genotype and phenotype analysis and on the epidemiology of the disorders of blood coagulation. This is an invaluable text for clinicians and laboratory scientists who want to unravel the molecular basis of inherited disease, presented with a patient with either a bleeding or thrombotic disorder.

Blood coagulation disorders --- Blood Coagulation Disorders --- Blood Coagulation Factors --- Blood Coagulation --- Genetic aspects. --- Genetics. --- Genetics. --- Genetics.

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Plant diseases --- Bacterioses --- Rhizobium --- Symbiosis --- Pathogens --- Disease resistance --- Plant response --- breeding methods --- genetic transformation --- Genetic control --- Plant and Crop Sciences. Diseases, Pests and Disorders of Plants --- Host Parasite Relationships --- Microbe-Plant Relations --- Microbe-Plant Relations. --- Plant-microbe relationships --- Genetic aspects --- Congresses --- Molecular aspects --- Congresses. --- Plant-microbe relationships - Genetic aspects - Congresses --- Plant-microbe relationships - Molecular aspects - Congresses